Acute Sleep Loss and Plasma Biomarkers of Brain Health

In young, healthy men, plasma levels of total tau but not amyloid were elevated after acute sleep loss.

Biomarkers in the cerebrospinal fluid (CSF) have shown changes after acute sleep loss, but data are limited on how acute sleep loss affects plasma levels. In this two-condition cross-over study, investigators obtained plasma cerebral biomarker levels in 15 young, healthy men (mean age, 22 years) after one night of acute sleep loss and one night of normal sleep in a controlled laboratory environment. The investigators measured participants' fasting plasma levels of amyloid beta-42 (Aβ42), amyloid beta-40 (Aβ40), total tau, neurofilament light protein, and glial fibrillary acidic protein (GFAP) at 19:30 and 7:30 hours. The participants either slept or stayed awake between 22:30 and 7:00 hours.

Compared with normal sleep, plasma total tau level…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Acute Sleep Loss and Plasma Biomarkers of Brain Health

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Reviewing Author