Does Prenatal Vitamin D Reduce Asthma in School-Aged Children?

High-dose vitamin D supplementation during pregnancy did not reduce asthma or recurrent wheezing in children at 6 years of age.

There is speculation that vitamin D may play a role in the development of asthma and other allergic diseases. In the prior Vitamin D Antenatal Asthma Reduction Trial (VDAART; JAMA 2016; 315:362), pregnant women with risk factors for asthma (asthma, eczema, or allergic rhinitis) were randomized to prenatal supplementation with high-dose vitamin D3 (4400 IU daily) or placebo-dose vitamin D (400 IU daily) starting at 10 to 18 weeks' gestation and continued through delivery.

In that study, children born of mothers who received high-dose vitamin D had a nonsignificant reduction in asthma and recurrent wheezing (the primary outcome) at 3 years of age compared with those who received placebo-dose vitamin D (24% and 30%, respectively). Now, research…

Reviewing Author

David J. Amrol, MD

Disclosures

Speaker’s BureauAstraZeneca; Incyte

David J. Amrol, MD

Disclosures

Speaker’s BureauAstraZeneca; Incyte

Does Prenatal Vitamin D Reduce Asthma in School-Aged Children?

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Reviewing Author