For People with Lamin A/C Mutations, Long-Term Exercise Might Worsen Dilated Cardiomyopathy

Exercise, especially high-intensity exercise, is controversial in patients with cardiomyopathies, although data showing adverse outcomes exist only for arrhythmogenic right ventricular dysplasia. In this observational, retrospective, single-site study of 69 individuals with a pathologic lamin A/C gene mutation associated with dilated cardiomyopathy, researchers used surveys to assess exercise and then correlated duration and intensity of exercise with left ventricular ejection fraction (LVEF), N-terminal pro–B-type natriuretic peptide (NT-proBNP) level, and other indicators of cardiac function. The participants included 28 case patients with lamin A/C–related symptoms (68% with dilated cardiomyopathy) and 41 family members with lamin A/C mu…