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Experimental evidence suggests an association between sulfur-metabolizing microbes and colorectal carcinogenesis, both directly and via increased production of hydrogen sulfide (H2S). To further investigate this association, researchers analyzed detailed dietary data and colorectal cancer (CRC) incidence in over 51,000 men participating in the Health Professionals Follow-Up study.
Using stool samples from a nested cohort of about 300 healthy men, researchers identified food groups associated with 43 bacterial species involved in sulfur metabolism. A sulfur microbial dietary score was then developed and applied to the rest of the cohort to determine its association with incident CRC risk. Results were as follows:
There were 1,264 incident CRC …