Does Iodinated Contrast Enhancement of CT Cause Acute Kidney Injury in Children?

The first study to validate the safety of contrast media in kids with normal kidney function

Controversy exists as to the potential nephrotoxicity of intravenous iodinated radiocontrast media (ICM) in both adults and children. In the current retrospective study, researchers assessed the development of acute kidney injury (AKI) in 925 hospitalized children (mean age, 8 years) who underwent an ICM-enhanced CT scan and in a propensity score–matched cohort of 925 hospitalized children who underwent abdominal ultrasound imaging. Matching was rigorous, including 23 covariates. Results were as follows:

In each group, 889 children (96%) had an estimated glomerular filtration rate (eGFR) before imaging of ≥60 mL/min/1.73 m².
In children with eGFR ≥60 mL/min/1.73 m², incidence of AKI was identical (2.2%) in the ICM and matched control groups.
T…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Does Iodinated Contrast Enhancement of CT Cause Acute Kidney Injury in Children?

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Reviewing Author