Clinical Presentations of Patients with Paroxysmal Nocturnal Hemoglobinuria Clones

Among patients with PNH clones, 66% had cytopenias and 29% had hemolytic features.

Patients with paroxysmal nocturnal hemoglobinuria (PNH) have a variety of clinical features, including unexplained hemolysis, cytopenias, and thrombosis in unusual sites, such as the cerebral veins or splanchnic circulations. When evaluating patients with these features, hematologists test for PNH clones by peripheral blood flow cytometry.

To better understand presenting features and reconcile clinical heterogeneity within PNH, investigators retrospectively analyzed 1081 patients with PNH clones detected by flow cytometry over a 25-year period.

Key findings included the following:

The median age of patients with PNH clones was 49 years, and the most common blood count abnormalities included a low red-cell count (>90% of patients), low platelet…

Reviewing Author

Brady L. Stein, MD, MHS

Disclosures

Leadership Positions in Professional SocietiesAmerican Society of Hematology (Senior Editor, ASH Self-Assessment Program; guideline development)

Brady L. Stein, MD, MHS

Disclosures

Leadership Positions in Professional SocietiesAmerican Society of Hematology (Senior Editor, ASH Self-Assessment Program; guideline development)

Clinical Presentations of Patients with Paroxysmal Nocturnal Hemoglobinuria Clones

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Reviewing Author