Loading...
Although subclinical hypothyroidism is the most common form of thyroid disorder in both pregnancy and in patients with mood disorders, data on subclinical hypothyroidism and depressive symptoms in pregnancy are sparse. As part of a study of antenatal thyroxine therapy for subclinical thyroid disease (N Engl J Med 2017; 376:815), investigators conducted an ancillary trial involving 245 pregnant women with subclinical hypothyroidism (thyroid stimulating hormone [TSH] ≥4 mU/L, free thyroxine [T4] 0.86–1.90 ng/dL [normal]) who were randomized to receive daily levothyroxine (100 µg initially; adjusted to achieve TSH 0.1–2.5 mU/L) or placebo begun between 11 and 20 weeks' gestation and discontinued at delivery. Depressive symptoms were assessed a…