Do Proton-Pump Inhibitors Increase Risk for Fractures in Children?

PPIs do carry a small increased risk of fractures, especially in those treated for at least 1 year and in healthy children >6 years old.

Proton-pump inhibitors (PPIs) have been associated with increased risk for fractures in older adults. To assess risk in children, investigators examined records of all children <18 years old in the Swedish health registry from 2006 to 2016. Children who had previous fracture or relevant chronic conditions were excluded. Propensity scoring was used to compare 115,933 children (mean age, 12.6 years) newly receiving PPIs with a carefully matched control group.

During a mean 2 years of follow up, fractures occurred in 20.2% of the PPI group versus 18.3% of the control group (hazard ratio, 1.11). Risk was increased for fractures of the upper limb (HR, 1.08), lower limb (HR, 1.19) and “other” sites (HR, 1.51), but not head or spine. Fracture risk …

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Do Proton-Pump Inhibitors Increase Risk for Fractures in Children?

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Reviewing Author