To Reduce Multiple Pregnancies, Limit the Number of Mature Follicles

Ovarian stimulation followed by IUI for infertile women younger than 40 should probably be confined to cycles with no more than 2 mature follicles.

Ovarian stimulation followed by intrauterine insemination (IUI) increases the chances of multiple gestation. To examine this risk, investigators conducted a retrospective study of 24,649 patients undergoing 50,473 IUI cycles at a single fertility center. Ovarian stimulation was conducted with agents including clomiphene citrate, letrozole, and gonadotropins.

In women younger than 38, raising the number of mature follicles at IUI from 1 to 5 was associated with an increase in clinical pregnancy rates from 14.6% to 21.9% (adjusted odds ratio, 1.6), primarily due to an increase in multiple gestations per cycle from 0.6% to 6.5% (aOR, 9.9). Likelihood of a singleton pregnancy per IUI rose modestly (from 14.1% to 16.4%) regardless of the number o…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

To Reduce Multiple Pregnancies, Limit the Number of Mature Follicles

Topics

Reviewing Author