Effect of Statewide Reminder and Recall System on HPV Vaccination Rates

Centralized reminder and recall from state immunization information systems is effective in raising childhood vaccination rates, but the effect on human papillomavirus (HPV) vaccination rates is unknown. In this pragmatic trial at randomly selected practices in Colorado and New York, patients aged 11 to 17 years who had not completed the HPV vaccine series were randomized to receive 0, 1, 2, or 3 auto-dialer phone reminders for each dose; the calls appeared as a toll-free number on caller ID. Roughly 31,000 patients were enrolled in each state.

HPV vaccine initiation rates in the groups ranged from 37.0% to 37.4% in NY and 31.2% to 33.5% in CO. Completion rates were lower, ranging from 29.1% to 30.1% in NY and 27.0% to 27.8% in CO. In CO, in…