Targeted Interventions Hasten Malaria Elimination

Mass drug treatment and vector control in direct response to malaria cases were effective, safe, and feasible in low-endemic areas.

In low malaria-endemic areas, screening and treatment of cases found nearby passively detected cases — an approach known as reactive case detection (RACD) — has been ineffective. Mass drug treatment of entire populations has other problems, including cost, safety, and acceptability.

In a cluster-randomized trial in Namibia, investigators have now evaluated using reactive focal intervention strategies in response to identified malaria cases. They randomly assigned population clusters to four groups and compared RACD only, reactive focal mass drug administration (rfMDA) only, reactive focal vector control (RAVC) plus RACD, and rfMDA plus RAVC.

RACD involved rapid diagnostic testing and treatment (artemether-lumefantrine and single dose primaqui…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Targeted Interventions Hasten Malaria Elimination

Topics

Reviewing Author