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Most COVID-19 cases are in adults, but we are gaining data on the clinical effects of the virus in children (NEJM JW Pediatr and Adolesc Med Apr 2020 and MMWR Morb Mortal Wkly Rep 2020 Apr 10; 69:422). These investigators conducted a systematic review of articles published between December 1, 2019, and March 3, 2020, that included children ≤19 years of age with confirmed SARS-CoV-2 infection. They identified 17 studies from China and 1 from Singapore, which included 1065 cases. Findings include:
444 children were aged <10 years and 553 were aged 10 to 19 years (age was not provided for some).
Most children acquired infection after close contact with infected family members.
Clinical presentation was mild in all cases, with the exception of one…