Revisiting the Outcomes of Salpingectomy with or without Oophorectomy

Optimizing the type and timing of prophylactic surgery in BRCA mutation carriers.

Risk-reducing bilateral salpingo-oophorectomy (rrBSO) represents the standard of care for preventing ovarian cancer in women with BRCA germline mutations. This surgery is offered to such women when they have completed childbearing, by age 35 to 40 (BRCA1 carriers; lifetime risk of ovarian cancer, 39%–46%), or by age 40 to 45 (BRCA2; risk, 10%–27%). However, some carriers are reluctant to undergo BSO because of concerns about adverse effects (e.g., hot flashes, osteoporosis, cardiovascular or neurodegenerative disease) caused by early surgical menopause in the absence of hormone therapy. The fimbria of the fallopian tubes play a central role in the genesis of ovarian, tubal, and peritoneal cancers. Against this backdrop, some mutation carrie…

Reviewing Author

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Revisiting the Outcomes of Salpingectomy with or without Oophorectomy

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Reviewing Author