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Depression in older adults can have a negative impact on other chronic medical conditions. Although antidepressant response rates are similar in older adults and their younger counterparts, polypharmacy and a greater risk of adverse effects might make medication choice harder in an older population. The present researchers performed a focused, secondary analysis of 206 adults aged ≥65 from the manufacturer-sponsored, randomized, controlled GUIDED trial examining the clinical utility of combinatorial pharmacogenomic testing to guide antidepressant choice among adults with major depression (NEJM JW Psychiatry Mar 2019 and J Psychiatr Res 2019; 111:59).
Testing involved 59 alleles across 8 genes (e.g., CYP3A4, CYP2D6). Among the 184 completers …