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Little direct evidence supports the recommendation for repeat screening colonoscopy at 10 years after a negative study, and some evidence suggests that the benefit of a single negative colonoscopy might extend far longer. Researchers in Poland identified a cohort of more than 165,000 patients (mean age, 57; 65% women) who had single initial negative colonoscopies and compared their long-term incidence of colorectal cancer (CRC) and CRC-related mortality to that of the general population. About 68% of colonoscopies were deemed to be of low quality, primarily because endoscopists had detected adenomas in fewer than 20% of annual screening colonoscopies. Patients were followed for as long as 17.4 years.
The ratio of CRC incidence in screened ve…