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Over decades, researchers have hypothesized connections between multitudinous neurohormones and depression, and these hypotheses have resulted in complex theories, thousands of animal studies, and, typically, small clinical trials. Occasionally, new findings kindle enthusiasm for novel approaches. To assess the current field, the American Psychiatric Association's task force on novel biomarkers and treatments has provided an overview of the physiology of neurohormones, how these may affect depressive disorders, and studies of treatments involving major neuroendocrine systems.
The task force described these systems:
Hypothalamic-pituitary-adrenal (HPA) axis, including corticotropin-releasing factor receptor (CRFR1) and glucocorticoid receptor …