Invasive Breast Cancer and Associated Mortality After DCIS

In a large British observational study, ductal carcinoma in situ was associated with excess risk for invasive breast cancer and mortality that was mitigated by more-intensive treatment.

For ductal carcinoma in situ (DCIS), resection with clear margins is standard of care to avert invasive progression. Radiation after lumpectomy can reduce risk for local recurrence by 50%, and endocrine therapy can lower this risk by 30% while also reducing risk for contralateral breast cancer. Nonetheless, the long-term sequelae of DCIS are still poorly defined. In a large observational study, U.K. investigators used national breast screening data to evaluate >35,000 women with DCIS diagnosed from 1988 to 2014. Subsequent incidence of invasive breast-tumor recurrence (IBTR) and death from breast cancer were compared with expected rates in the general population of England and Wales; cumulative analyses were stratified by time since DCIS di…

Reviewing Author

Laila Samiian, MD, FACS

Disclosures

Leadership Positions in Professional SocietiesAssociation of Women Surgeons (Member, Publications Committee)

Laila Samiian, MD, FACS

Disclosures

Leadership Positions in Professional SocietiesAssociation of Women Surgeons (Member, Publications Committee)

Invasive Breast Cancer and Associated Mortality After DCIS

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Reviewing Author