Effectiveness and Safety of Endoscopic Duodenal Polypectomy and Papillectomy in Familial Adenomatous Polyposis

Endoscopic management was effective, though the adverse event rate was substantial.

Endoscopic prophylactic removal of large (≥10 mm) or advanced (containing high-grade dysplasia) ampullary or duodenal polyps may prevent the development of cancer in patients with familial adenomatous polyposis (FAP). As there are no medications to prevent duodenal polyps from progressing to cancer, the alternative is surgery, which is associated with substantial morbidity and mortality.

In a retrospective cohort study, experts at a referral center in the Netherlands reviewed outcomes in 49 patients who underwent 139 duodenal polypectomies (85% removed by endoscopic mucosal resection) and 29 patients who underwent duodenal papillectomy between 2002 and 2018. All procedures were primary resections, and all polyps had adenomatous visual charac…

Reviewing Author

John R. Saltzman, MD

Disclosures

Consultant/Advisory BoardIterative Scopes

Editorial BoardsGastrointestinal Endoscopy; UpToDate

Leadership Positions in Professional SocietiesAmerican College of Gastroenterology (Trustee)

OtherVice President of Medical Affairs, 1Globe Health Institute