What Distinguishes Breast Cancers Diagnosed Shortly After a Negative Screening Mammogram?

For multifaceted reasons, interval breast cancers were associated with higher breast cancer mortality than those detected by screening mammography.

Interval breast cancer (IBC) arising after a negative mammogram tends to have a worse prognosis than screen-detected cancer. To better understand the consequences, researchers conducted a secondary analysis of data from the Women's Health Initiative trials. They assessed breast cancer–specific mortality among almost 1970 women whose cancers were detected by screening mammography compared with those with IBC that was detected within 1 year (324 women) or between 1 and 2.5 years (726 women) after a negative mammogram.

Women with IBC diagnosed within 1 year of a negative screening mammogram were more likely to have lobular histology, larger tumors, and lymph node involvement. Such IBC was associated with excess breast cancer specific mortality …

Reviewing Author

Laila Samiian, MD, FACS

Disclosures

Leadership Positions in Professional SocietiesAssociation of Women Surgeons (Member, Publications Committee)

Laila Samiian, MD, FACS

Disclosures

Leadership Positions in Professional SocietiesAssociation of Women Surgeons (Member, Publications Committee)

What Distinguishes Breast Cancers Diagnosed Shortly After a Negative Screening Mammogram?

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Reviewing Author