Ticagrelor plus Aspirin for Minor Stroke or TIA

A randomized trial supports this treatment as a new option for secondary stroke prevention in these patients.

The main treatment options for acute minor stroke or transient ischemic attack (TIA) currently are aspirin (A) alone or with clopidogrel (A+C). Ticagrelor (T) reversibly binds and inhibits the P2Y12 receptor on platelets and is widely used to prevent vascular events caused by ischemic heart disease. To test A+T in patients with stroke or TIA, researchers conducted a multicenter, manufacturer-sponsored trial involving 11,016 patients (mean age, 65 years; 39% women; 77% with hypertension, 29% with diabetes), mostly from Europe and Asia. Participants had a mild stroke (NIH Stroke Scale score ≤5) or a high-risk TIA starting within 24 hours before enrollment and did not receive thrombolysis or thrombectomy or require anticoagulation. Participant…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Ticagrelor plus Aspirin for Minor Stroke or TIA

Topics

Reviewing Author