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The relatively small number of older adults who have been enrolled in prior randomized, controlled trials (RCTs) of statins has led to uncertainty regarding their value in primary prevention of atherosclerotic cardiovascular disease. Investigators used the Veterans Health Affairs database to perform a retrospective cohort study of about 327,000 patients (age, ≥75; mean age, 81; mostly white men) without prior statin use; about 57,000 received new statin prescriptions during mean follow-up of 7 years. Patients with any form of cardiovascular disease at baseline and those who died within 150 days of enrollment were excluded. Patients with cancer, dementia, or paralysis were not excluded.
Crude cardiovascular-related mortality for statin users …