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Clostridioides difficile infection (CDI) can be acquired in the hospital or the community, but the vast majority are associated with exposure to the healthcare system. (See the 2017 IDSA/SHEA guidelines.) The risk of transmission from an infected household member to other family members is not well defined. Now a study examines that risk.
Using information from both commercial and Medicare insurance claims, investigators performed a case-control study analyzing CDI cases from 2001 through 2017. In some 225,000 CDI events at least two family members were enrolled in the same insurance database. Of these, 1074 had been exposed to a family member with CDI in the previous 60 days (4.8% of total cases). The adjusted incidence rate ratio (IRR) for…