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In both animals and humans, regular exercise improves neurogenesis and cognition. Transfer of blood from young mice to old mice also improves neurogenesis and cognition, which suggests that such improvements are mediated by specific molecules. Might benefits of exercise on the aging brain be conferred by such molecules?
A series of experiments demonstrated several things:
In older mice, regular exercise, compared with sedentary behavior, improved neurogenesis, learning ability, and memory.
Blood extracted from older, midlife, or younger exercising mice that was injected intravenously into older sedentary mice produced improved neurogenesis, learning ability, and memory; blood infusions from sedentary mice did not have this effect.
Mass spectrom…