Does Vitamin D Supplementation Protect Against Type 2 Diabetes?

A meta-analysis suggests that doses ≥1000 IU daily modestly lower incidence in people with prediabetes and lower body mass.

Low blood levels of 25-hydroxyvitamin D (25[OH]D) are associated with impaired insulin secretion, increased insulin resistance, and increased incidence of type 2 diabetes. Vitamin D supplementation decreases fasting blood sugar and glycosylated hemoglobin (HbA_1c) levels in some studies.

Investigators conducted a meta-analysis of nine randomized, controlled trials (RCTs) of the effects of vitamin D supplementation on incidence of type 2 diabetes (43,600 participants). Participants were followed for at least 1 year. The quality of the studies was judged to be good. Results were analyzed separately for higher (≥1000 IU) and lower (<1000 IU) daily doses of vitamin D. In people with prediabetes who took higher vitamin D doses, incidence of type 2…

Reviewing Author

Anthony L. Komaroff, MD

Disclosures

Consultant/Advisory BoardSerImmune Inc.; DxTerity

Grant / Research SupportNIH (1U54NS105542-01)

Editorial BoardsHarvard Health Letter; UpToDate

Anthony L. Komaroff, MD

Disclosures

Consultant/Advisory BoardSerImmune Inc.; DxTerity

Grant / Research SupportNIH (1U54NS105542-01)

Editorial BoardsHarvard Health Letter; UpToDate

Does Vitamin D Supplementation Protect Against Type 2 Diabetes?

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Reviewing Author