What's the Duration of Immunity to SARS-CoV-2?

Individuals with mild COVID-19 infection have a rapid decline in SARS-CoV-2 antibody levels.

One of the many still unanswered questions regarding COVID-19 is the duration of protective immunity following infection. A recent report from China indicated that individuals with asymptomatic COVID-19 had a less robust immune response to SARS-CoV-2 (NEJM JW Infect Dis Sep 2020 and Nat Med 2020 Jun 18; [e-pub]). California investigators now report further longitudinal data on antibody levels after mild COVID-19.

Thirty-four individuals with mild COVID-19 (30 that were polymerase-chain-reaction assay confirmed) had serial anti–SARS-CoV-2 receptor binding domain IgG levels determined at a mean of 37 and 86 days after symptom onset. The estimated mean IgG half-life was 36 days.

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

What's the Duration of Immunity to SARS-CoV-2?

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Reviewing Author