COVID-19 Vaccines Protect Nonhuman Primates from Infection

Both mRNA-based and adenovirus-based COVID-19 vaccines were able to protect nonhuman primates against direct SARS-CoV-2 challenge.

Whether potential COVID-19 vaccines will induce protective immunity against the SARS-CoV-2 virus remains a key unanswered question. Two groups addressed this concern in nonhuman primates in two partially manufacturer-supported studies.

Corbett and associates immunized groups of 8 rhesus macaques with two doses, given 4 weeks apart, of either 10 μg or 100 μg of the mRNA-1273 SARS-CoV-2 vaccine. Both vaccine doses elicited SARS-CoV-2 binding and neutralizing antibodies at higher levels than found in convalescent samples from 42 human COVID-19 patients. Both vaccine doses similarly induced a CD4 Th1 immune response, but not the CD4 Th2 response that has been associated with vaccine-enhanced respiratory disease. After combined intratracheal and …

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

COVID-19 Vaccines Protect Nonhuman Primates from Infection

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Reviewing Author