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Target Population: Adults with pain from musculoskeletal injuries that do not involve the lower back.
Treating patients who have acute musculoskeletal injuries (e.g., sprains, strains, contusions, whiplash, nonsurgical fractures of ribs and toes) is the bread and butter of outpatient medicine. Authors from the sponsoring organizations reviewed 207 trials that included more than 30,000 participants, most younger than 40, with these injuries.
For immediate pain relief, best-quality evidence supported use of acetaminophen alone or combined with oral diclofenac or an opioid. Use of oral or topical nonsteroidal anti-inf…