An Increase in Invasive Pneumococcal Disease

Invasive pneumococcal disease due to serotype 4 increased up to 300-fold in 2018 among adults in California, Colorado, and New Mexico.

Following the introduction in 2000 of the pneumococcal 7-valent conjugate vaccine (PCV7), the incidence of invasive pneumococcal disease (IPD) decreased markedly. However, since 2013, and after PCV7 had been supplanted by the 13-valent vaccine (PCV13), the incidence of IPD from serotype 4, which is covered by both vaccines, has increased.

To further assess this recent trend, investigators at the CDC identified cases of IPD from 2010 through 2018 based on the isolation of Streptococcus pneumoniae from a normally sterile site using the Active Bacterial Core Surveillance system (ABCs). The researchers were also able to identify which patients were persons experiencing homelessness (PEH).

Results were as follows:

The incidence of serotype 4 IPD in…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

An Increase in Invasive Pneumococcal Disease

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Reviewing Author