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Colorectal cancer (CRC) is an attractive target for chemoprevention given its long latency. In this umbrella review of 80 systematic reviews and meta-analyses published between 1980 and 2019, investigators assessed the effects of a variety of chemopreventive agents on CRC risk in average-risk persons. The results were as follows:
Agents found to be chemoprotective were aspirin (effect range, −14% to −29%), nonsteroidal anti-inflammatory drugs (−27% to −43%), magnesium (−11% to −22%), folate (−12% to −15%), fiber (−22% to −43%), dairy products (−13% to −19%), fruits and vegetables (−8% to −52%), and soy (−8% to −15%).
The effects of coffee, fish, calcium, vitamin A, group B vitamins, and statins were uncertain, with some analyses showing prote…