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To investigate correlations between affective and conduct symptoms — assessed by mothers at children's ages 7 and 11 and mothers and teachers at age 16 — and standard biomarkers for inflammation and cardiovascular risk in adulthood (age, 44–45) and premature death, researchers prospectively followed all infants born in a single week in Great Britain in 1958; 9377 participants had biomarker data at the midlife follow-up.
Data analysis revealed four groups: stable-low (no affective symptoms or conduct problems into adulthood); teacher-identified adolescent onset (TIAO; no symptoms at ages 7 and 11, conduct and some affective symptoms noted by teachers at age 16); moderate (moderate conduct and affective symptoms at age 7, which decreased by ag…