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A multisystem inflammatory syndrome associated with SARS-CoV-2 infection has been defined in some children (MIS-C). Researchers now report on 27 cases of a similar syndrome in adults (MIS-A) identified in the U.S. or U.K. since June 2020. The case definition of MIS-A required (1) hospitalization without evidence of severe respiratory illness (to exclude hypoxia as the cause of the signs and symptoms), (2) extrapulmonary organ system involvement (including hypotension or shock, cardiac dysfunction, arterial or venous thromboembolism, acute liver injury, or dermatologic abnormalities), and (3) laboratory evidence of acute inflammation (e.g., highly elevated C-reactive protein, ferritin, D-dimer, or interleukin-6).
Of 16 patients fitting this d…