Updated IAS-USA ART Treatment and Prevention Guidelines for Adults

Updated guidelines reflect further endorsement of mostly integrase strand inhibitor–based regimens and a tacit recommendation of injectable long-acting antiretroviral drugs for treatment and prevention in certain populations.

Sponsoring Organization: International Antiviral Society–USA

Background and Objective

A panel of 15 HIV experts reviewed 539 recent peer-reviewed articles (through August 22, 2020) to rate and update the 2018 antiretroviral therapy (ART) recommendations.

Key Points

ART is recommended for all persons with detectable viremia.
Treatment usually should be started as soon as possible.
Most patients can be treated initially with any of various three-drug ART regimens or, in select populations, a two-drug regimen containing an integrase strand transfer inhibitor.
Specific recommendations focus on certain patient groups: pregnant women, persons with significant comorbidities, and those with common opportunistic infections.
The panel makes recommendations a…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes