Prehospital Tranexamic Acid Does Not Improve Mortality in Undifferentiated Trauma Patients

However, it did confer a mortality benefit when given within 1 hour or to patients in severe shock in this randomized, controlled trial.

Tranexamic acid (TXA) has been shown to lower mortality in patients with severe trauma, especially when given within 1 hour of injury (NEJM JW Emerg Med Jul 2010 and Lancet 2010; 376:23; NEJM JW Emerg Med May 2011 and Lancet 2011; 377:1096). These investigators performed a randomized, controlled trial to evaluate TXA for injured patients at risk for hemorrhage. They enrolled 927 patients with hypotension or tachycardia being transported from the scene or a referral hospital within 2 hours of injury. Notable exclusions were age >90 years, lack of IV access, and traumatic cardiac arrest. Patients were randomized to receive placebo or TXA (1-g bolus) during transport. At the trauma center, patients in the TXA group were randomized again to no …

Reviewing Author

Ali S. Raja, MD, MBA, MPH

Disclosures

Leadership Positions in Professional SocietiesSociety for Academic Emergency Medicine (Board Member); American College of Healthcare Executives – Massachusetts (Board Member)

Ali S. Raja, MD, MBA, MPH

Disclosures

Leadership Positions in Professional SocietiesSociety for Academic Emergency Medicine (Board Member); American College of Healthcare Executives – Massachusetts (Board Member)

Prehospital Tranexamic Acid Does Not Improve Mortality in Undifferentiated Trauma Patients

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Reviewing Author