Adults and Children with Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) has several presentations, such as neuromyelitis optica spectrum disorder and acute disseminated encephalomyelitis (ADEM). To examine differences between children and adults with MOGAD, investigators studied patients from all French tertiary hospitals who had an acute clinical demyelinating episode, presence of MOG-Ab, and at least 6 months of follow-up.

A total of 366 patients with MOG-Ab were included. Median age at onset was 30 years and 54% were female. Isolated optic neuritis (ON) was the most common initial event (56% of adults, 41% of children), followed by ADEM (6% of adults, 37% of children). At last follow-up, Expanded Disability Status Scale score was ≥3.0 in …