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To see whether smoking cigarettes with low-nicotine content would lower tobacco use in high-risk individuals, researchers conducted three parallel, 12-week, multisite, randomized, clinical trials in 775 smokers not planning to quit. Three populations were studied — patients with opioid use disorder, patients with affective disorders, and women with high-school education or less (a socioeconomically disadvantaged group).
The three study arms were cigarettes with nicotine content similar to commercial cigarettes (15.8 mg nicotine per g tobacco) and two low-nicotine cigarettes (2.4 mg/g and 0.4 mg/g). Cigarette supply was unlimited and free, participants were counseled to use only study cigarettes, and participants reported cigarette consumptio…