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Observational studies have suggested associations between use of proton-pump inhibitors (PPIs) and COVID-19 (NEJM JW Gastroenterol Sep 2020 and Am J Gastroenterol 2020; 115:1707). In two meta-analyses, researchers now have addressed this issue, with the following findings:
In one meta-analysis, “current or regular use” of PPIs was associated with nonsignificantly higher risk for becoming infected with SARS-CoV-2 (5 studies; odds ratio, 1.33) and with significantly higher risk for severe outcomes of COVID-19, including intensive care unit admission or death (9 studies; OR, 1.67).
In another meta-analysis, PPI use was associated with significantly higher risk for severe outcomes of COVID-19 (3 studies; OR, 1.46) and for developing secondary inf…