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In patients with acute traumatic pain, the relative efficacy of acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), or their combination is unclear. Researchers in Tunisia enrolled 1500 nonhospitalized adults (mean age, 37) who presented to a single emergency department (ED) with moderate-to-severe acute traumatic extremity pain (mean pain score, 6.3 of 10). Patients with open fractures or torso trauma were excluded.
Participants were randomized to 7 days of acetaminophen (1000 mg every 8 hours), piroxicam (20 mg twice daily), or both. The primary outcome, use of other pain medications outside of the study drugs, occurred in 11%, 18%, and 10% of the acetaminophen, NSAID, and combination groups, respectively. Patients who received o…