In a two-decade U.K. study, the differential was broad, with multiple sclerosis most common but a majority lacking MS.
The differential for optic neuritis (ON) is broad. While multiple sclerosis (MS) is at the top of the list, various other neurologic and systemic diseases can also cause ON. Investigators used a U.K. National Health Service database to evaluate 22-year trends in ON. Patients for this case-control and matched-cohort study presented between 1995 and 2019.
Cases of ON included 2826 individuals. Annual incidence of ON remained relatively stable, between 3 and 4 per 100,000 person-years. Factors associated with ON included age 21 to 30, female sex, elevated body-mass index, and past or current smoking. Patients with ON had higher odds of MS, syphilis, mycoplasma infection, vasculitis, sarcoidosis, Epstein-Barr virus infection, Crohn disease, psor…
Reviewing Author
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)