Tranexamic Acid Treatment Fails in Subarachnoid Hemorrhage Treatment

Even when treatment started at a median of about 3 hours after onset, 6-month outcomes were no better than with usual care.

Subarachnoid hemorrhage (SAH) is one of the stroke types associated with high levels of mortality and is frequently caused by a ruptured brain aneurysm. Early treatment of the aneurysm with either clipping or coiling is recommended. Whether antifibrinolytic treatment improves outcomes is unclear. These authors conducted a randomized trial of tranexamic acid (TXA) versus usual care for patients with SAH. Eligible patients had nontraumatic SAH shown by computed tomography (CT). Treatment with TXA included a bolus dose of 1 g intravenously (IV), followed by 1 g IV every 8 hours. Treatment continued either for 24 hours maximum or until definitive aneurysm treatment was performed. The primary study endpoint was good outcome on the modified Ranki…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Tranexamic Acid Treatment Fails in Subarachnoid Hemorrhage Treatment

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Reviewing Author