Risk for Neurologic Worsening in Minor Stroke with Large-Vessel Occlusion

A novel score might aid decisions about further treatment for minor-stroke patients with early deterioration.

Treatment with endovascular thrombectomy (EVT) for patients with an acute stroke and large-vessel occlusion (LVO) is recommended only for those with “nonminor” deficits and a documented NIH Stroke Scale (NIHSS) score ≥6.

These authors analyzed a multicenter registry of patients with minor stroke (NIHSS score of ≤5) who were treated with alteplase to determine the frequency of early neurologic deterioration (END) — defined as an increase of ≥4 points on the NIHSS within 24 hours after alteplase administration — and factors associated with END. Based on these results, they constructed a score to predict END. They also evaluated outcomes of patients with END who did and did not undergo rescue thrombectomy.

In a derivation group of 729 patients (…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Risk for Neurologic Worsening in Minor Stroke with Large-Vessel Occlusion

Topics

Reviewing Author