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Based on evidence collected during the past decade, a 2020 international guideline (World J Emerg Surg 2020; 15:27) recommends discussing antibiotics as a safe alternative to surgery for managing uncomplicated acute appendicitis (defined as the absence of an appendicolith, perforation, or abscess). In previous studies, researchers evaluated intravenous (IV) antibiotics with transition to oral antibiotics. However, the effectiveness of a single oral antibiotic regimen has not been studied.
In this open-label trial, conducted in 9 Finnish hospitals, 600 adults (median age, 34) with uncomplicated acute appendicitis confirmed by computed tomography were randomized to oral moxifloxacin (400 mg daily) for 7 days or to IV ertapenem for 2 days follo…