How Long Does Immunity Last After Recovery from Mild COVID-19?

Two studies suggest the adaptive immune response in COVID-19 is durable and continues to be shaped by viral remnants.

Our understanding of the immunity naturally conferred through SARS-CoV-2 infection is critical for gaining control of the COVID-19 pandemic. Immunologic memory is based on activation, expansion, and differentiation of B and T lymphocytes with viral neutralizing properties. With reexposure, these reactivated cell lines coordinate to clear the virus, preventing or mitigating disease and reducing transmission. Is this response durable in the setting of COVID-19?

Rodda et al. examined plasma and peripheral blood cells from 15 patients who recovered from mild COVID-19 (median duration of symptoms, 13 days) and 17 healthy controls. COVID-19 induced SARS-CoV-2–specific IgG antibodies, neutralizing plasma, and memory B and T lymphocytes that persist…

Reviewing Author

George Sakoulas, MD

Disclosures

Consultant/Advisory BoardParatek Pharmaceuticals; Nestle Corp.; AbbVie; Shionogi

Speaker’s BureauAllergan/AbbVie; Paratek Pharmaceuticals; Nestle Corp.

RoyaltiesUpToDate

Editorial BoardsAntimicrobial Agents and Chemotherapy; Open Forum Infectious Diseases