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Transient ischemic attacks (TIAs) are a well-recognized precursor to a potential ischemic stroke. Whether the short-term and long-term risks for stroke following TIA have decreased in recent decades has not received much study. Investigators from the Framingham Study have now evaluated these risks in a large database of participants dating back to 1948. Regular surveillance for stroke occurred, and investigators evaluated stroke at various time points (7 days, 30 days, 90 days, and up to 10 years). Those with incident TIA were matched to TIA-free participants in a 1:5 ratio.
Overall, during 66 years of follow-up, the TIA incidence rate was 1.19/1000 person-years. Participants with a TIA had an approximately fivefold higher rate of stroke tha…