Can Antioxidants Affect Risk for Parkinson Disease?

Vitamins E and C may be associated with risk, but the evidence remains limited.

To determine whether risk for future Parkinson disease (PD) diagnosis was reduced with increased dietary antioxidant intake and total nonenzymatic antioxidant capacity (NEAC), researchers examined data from 43,865 men and women (aged 18–94 at baseline) in the Swedish National March Cohort linked to the National Health Registries. The authors collected information on intakes of dietary vitamin E, vitamin C, and beta-carotene and determined NEAC on a food-frequency questionnaire. The investigators adjusted dietary exposure variables for energy intake and employed a multivariable Cox proportional hazard regression model.

During a mean follow-up of 17.6 years, 465 incident cases of PD occurred. Baseline vitamin E consumption was inversely associ…

Reviewing Author

Michael S. Okun, MD

Disclosures

Consultant/Advisory BoardParkinson’s Foundation; Tourette Association of America

Speaker’s BureauMedscape/WebMD CME, Movement Disorders Society CME, American Academy of Neurology CME

RoyaltiesBooks4Patients; Demos; Cambridge; Taylor and Francis; Robert Rose; Public Affairs

Grant/Research SupportNational Institutes of Health; Parkinson’s Foundation; Tourette Association of America; University of Florida Foundation

Editorial BoardsTremor and Other Hyperkinetic Movements; JAMA Neurology

Leadership Positions in Professional SocietiesParkinson’s Foundation (Medical Advisor)