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Guidelines recommend intravenous (IV) albumin for patients with cirrhosis after large-volume paracentesis and for patients with spontaneous bacterial peritonitis or hepatorenal syndrome (Hepatology 2013; 57:165). In vitro data suggest albumin's anti-inflammatory effects might ameliorate inflammation, infection, or kidney injury in patients with cirrhosis. British investigators randomized 777 patients with low serum albumin levels (i.e., <3 g/dL) who were admitted for decompensated cirrhosis (i.e., new or worsening ascites, encephalopathy, or variceal bleeding) to receive either standard care or daily IV albumin infusions (20% human albumin at 100–400 mL daily; titrated, based on serum albumin level, to a goal of 3.5 g/dL, for as long as 14 …