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Although face masks are an important tool to reduce spread of SARS-CoV-2, whether they are safe for children <2 years is unknown. Investigators in Italy studied this question in a cohort of 22 healthy children aged 4 to <24 months (median, 12.5 months; group A) and 25 children aged 24 to 144 months (median, 100 months; group B). They measured the children's partial pressure of end-tidal CO2 (PET CO2), oxygen saturation (SaO2), respiratory rate (RR), pulse rate (PR), and perfusion index (PI) 15 minutes before and 0, 15, and 30 minutes after two 30-minute study periods of usual play. The children wore surgical masks with three layers in the second period. Group B children also were tested after 12 minutes of brisk walking while wearing masks.…