Optical Coherence Tomography and Disability in Multiple Sclerosis

In a longitudinal study, baseline ganglion cell layer thickness was associated with disability 10 years later.

Optical coherence tomography (OCT) is a noninvasive retinal scan that is used increasingly in neurologic practice. Prior studies have shown that risk of future disability is higher for those with decreased retinal nerve fiber layer (RNFL) thickness (NEJM JW Neurol May 2016 and Lancet Neurol 2016; 15:574). In 132 patients with multiple sclerosis (MS), investigators have now evaluated baseline ganglion cell plus inner plexiform layer (GCIPL) thickness and Expanded Disability Status Scale (EDSS) at baseline and at a median follow-up of 10 years.

An average GCIPL of <70 microns was associated with an adjusted odds ratio of 3.97 for worsening disability compared with ≥70 microns and with an adjusted OR of 2.93 for worsening vision on 2.5% contras…

Reviewing Author

Robert T. Naismith, MD

Disclosures

Consultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics

Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense

Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)

Robert T. Naismith, MD

Disclosures

Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense

Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)

Optical Coherence Tomography and Disability in Multiple Sclerosis

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Reviewing Author