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The Centers for Medicare & Medicaid Services implemented the Sepsis Performance Measure (SEP-1) in 2015, which requires U.S. hospitals to report adherence to a sepsis bundle, including diagnostic measures (i.e., blood cultures and lactate levels) and therapeutic measures (i.e., timely antibiotics and intravenous fluids administration and vasopressors for refractory hypotension). University of Pittsburgh investigators evaluated the effects of SEP-1 implementation on processes and outcomes among >54,000 adult patients hospitalized with sepsis — defined as suspected infection and organ failure (Sequential Organ Failure Assessment, ≥2) — at 11 hospitals within an integrated healthcare system during 5 years. Outcomes were adjusted for comorbidit…