People with scores ≥1000 have elevated risks for cardiovascular disease, non-CVD, and total mortality.
Increasingly, studies are validating the prognostic importance of coronary artery calcium (CAC). An open question is the implication of very high CAC scores, i.e., those ≥1000. In an analysis receiving some industry support, researchers examined the relationship between very high CAC scores and cardiovascular outcomes in 6814 ethnically diverse people who participated in the Multi-Ethnic Study of Atherosclerosis (MESA) and did not have a cardiovascular disease (CVD) diagnosis at baseline.
Of the cohort, 257 (3.8%) had a CAC score ≥1000. In people with these very high scores, a mean of 3.4 coronary vessels were affected. The mean follow-up was 14 years, and final models adjusted for traditional risk factors and demographics. Compared with par…
Reviewing Author
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association