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For secondary prevention of cardiovascular (CV) events with aspirin, how do 81-mg and 325-mg doses compare? In this study, 15,000 U.S. patients with histories of atherosclerotic CV disease were randomized to receive one of these two doses daily. The trial was conducted through a national clinical research network in which recruitment, data collection, and follow-up were all conducted “virtually” (online or by phone). Patients were instructed to purchase their assigned aspirin themselves.
During median follow-up of 26 months, intent-to-treat analysis revealed no differences between groups in the incidence of the primary effectiveness outcome (i.e., myocardial infarction, stroke, or all-cause death) or the incidence of hospitalization for majo…